Tfdp1^tm1Lili
Targeted Allele Detail

Summary

• Symbol: Tfdp1^tm1Lili
• Name: transcription factor Dp 1; targeted mutation 1, Lili Yamasaki
• MGI ID: MGI:2653309
• Synonyms: Dp1^-
• Gene: Tfdp1 Location: Chr8:13388751-13428448 bp, + strand Genetic Position: Chr8, 5.78 cM, cytoband A1-A3
• Alliance: Tfdp1^tm1Lili page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:81580
• Parent Cell Line: D3 (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The gene was disrupted by replacement of exons 4-9 with a neomycin resistance cassette in the opposite orientation. The targeted mutation results in deletion of amino acids 66-330. Absence of gene expression in homozygous mutant E9.5 embryos was confirmed by Western blot analysis. (J:81580)

Expression

In Mice Carrying this Mutation:	25 assay results
In Structures Affected by this Mutation:	2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Tfdp1 Mutation: 41 strains or lines available

References

• Original: J:81580 Kohn MJ, et al., Dp1 is required for extra-embryonic development. Development. 2003 Apr;130(7):1295-305
• All: 1 reference(s)