Nr1h2^tm1Gstr
Targeted Allele Detail

Summary

• Symbol: Nr1h2^tm1Gstr
• Name: nuclear receptor subfamily 1, group H, member 2; targeted mutation 1, Gertrud Schuster
• MGI ID: MGI:2653319
• Synonyms: LXRbeta^hyp, LXR^hyp
• Gene: Nr1h2 Location: Chr7:44199040-44203375 bp, - strand Genetic Position: Chr7, 28.83 cM
• Alliance: Nr1h2^tm1Gstr page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:82096
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A single loxP site was inserted into intron 4 and a floxed neo cassette was inserted downstream of exon 6 via homologous recombination. (J:82096)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Nr1h2 Mutation: 26 strains or lines available

References

• Original: J:82096 Alberti S, et al., Hepatic cholesterol metabolism and resistance to dietary cholesterol in LXRbeta-deficient mice. J Clin Invest. 2001 Mar;107(5):565-73
• All: 3 reference(s)