Paxip1^tm1Gdr
Targeted Allele Detail

Summary

• Symbol: Paxip1^tm1Gdr
• Name: PAX interacting (with transcription-activation domain) protein 1; targeted mutation 1, Gregory R Dressler
• MGI ID: MGI:2653321
• Synonyms: PTIP^-
• Gene: Paxip1 Location: Chr5:27945078-27996689 bp, - strand Genetic Position: Chr5, 13.23 cM, cytoband A3
• Alliance: Paxip1^tm1Gdr page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:82319
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Sequence encompassing exons 1 through 3 was replaced with a neo cassette inserted by homologous recombination. No protein was detected in homozygous mutant embyros by Western blot analysis. (J:82319)

Expression

In Structures Affected by this Mutation:

5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Paxip1 Mutation: 47 strains or lines available

References

• Original: J:82319 Cho EA, et al., BRCT domain-containing protein PTIP is essential for progression through mitosis. Mol Cell Biol. 2003 Mar;23(5):1666-73
• All: 5 reference(s)