Nr1h3^tm1.1Gstr
Targeted Allele Detail

Summary

• Symbol: Nr1h3^tm1.1Gstr
• Name: nuclear receptor subfamily 1, group H, member 3; targeted mutation 1.1, Gertrud Schuster
• MGI ID: MGI:2653344
• Synonyms: LXRalpha^-
• Gene: Nr1h3 Location: Chr2:91014406-91033179 bp, - strand Genetic Position: Chr2, 50.52 cM
• Alliance: Nr1h3^tm1.1Gstr page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:82096
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: This allele is derived from Nr1hr^tm1Gstr. Exons 4 and 5 were deleted by mating Nr1h3^tm1Gstr animals to cre deleter strain TgN(CMV-cre)1Cgn. Northern blot analysis of liver RNA from homozygous mutant animals detected a mutant transcript lacking 500 nucleotides corresponding to exons 4 and 5. (J:82096)

Disease models

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Nr1h3^tm1.1Gstr

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Nr1h3 Mutation: 32 strains or lines available

References

• Original: J:82096 Alberti S, et al., Hepatic cholesterol metabolism and resistance to dietary cholesterol in LXRbeta-deficient mice. J Clin Invest. 2001 Mar;107(5):565-73
• All: 49 reference(s)