Plcb2^tm1Dwu
Targeted Allele Detail

Summary

• Symbol: Plcb2^tm1Dwu
• Name: phospholipase C, beta 2; targeted mutation 1, Dianqing Wu
• MGI ID: MGI:2653348
• Gene: Plcb2 Location: Chr2:118537998-118558919 bp, - strand Genetic Position: Chr2, 59.43 cM
• Alliance: Plcb2^tm1Dwu page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:41948
• Parent Cell Line: CJ7 (ES Cell)
• Strain of Origin: 129S1/Sv-Oca2⁺ Tyr⁺ Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: Sequence encoding the X box was disrupted by the insertion of a neomycin selection cassette. Western blot analysis of spleen and thymus extracts showed an absence of protein. (J:41948)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Plcb2^tm1Dwu

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Plcb2 Mutation: 54 strains or lines available

References

• Original: J:41948 Jiang H, et al., Roles of phospholipase C beta2 in chemoattractant-elicited responses. Proc Natl Acad Sci U S A. 1997 Jul 22;94(15):7971-5
• All: 19 reference(s)