Foxa1^tm1Gsc
Targeted Allele Detail

Summary

• Symbol: Foxa1^tm1Gsc
• Name: forkhead box A1; targeted mutation 1, Gunther Schutz
• MGI ID: MGI:2653543
• Synonyms: HNF3alpha-, HNF3alpha^lacZ
• Gene: Foxa1 Location: Chr12:57587414-57593702 bp, - strand Genetic Position: Chr12, 24.7 cM
• Alliance: Foxa1^tm1Gsc page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:53312
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A lacZ-neomycin resistance cassette replaced most of exon 2, which contains the entire DNA binding domain, and placed lacZ under control of the endogenous promoter. RNase protection assays of livers from postnatal day 8 mice detected no difference in mRNA levels between homozygous mutant mice and wild-type mice. (J:53312)

Expression

In Mice Carrying this Mutation:	74 assay results 2 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Foxa1 Mutation: 21 strains or lines available

References

• Original: J:53312 Kaestner KH, et al., Inactivation of the winged helix transcription factor HNF3alpha affects glucose homeostasis and islet glucagon gene expression in vivo. Genes Dev. 1999 Feb 15;13(4):495-504
• All: 14 reference(s)