Il13ra2^tm1Gru
Targeted Allele Detail

Summary

• Symbol: Il13ra2^tm1Gru
• Name: interleukin 13 receptor, alpha 2; targeted mutation 1, Michael Grusby
• MGI ID: MGI:2653910
• Synonyms: IL-13Ralpha2^-
• Gene: Il13ra2 Location: ChrX:146166472-146212188 bp, - strand Genetic Position: ChrX, 68.46 cM
• Alliance: Il13ra2^tm1Gru page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:82376
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Sequence encoding the start codon and signal peptide was deleted by homologous recombination of a targeting vector. Western blot analysis of sera obtained from homozygous mutant mice indicated an absence of protein. (J:82376)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Il13ra2 Mutation: 7 strains or lines available

Notes

"Male IL-13Ralpha2^-/- mice were generated from (129 x C57BL/6) mice and were backcrossed onto the BALB/c strain." J:82376

References

• Original: J:82376 Wood N, et al., Enhanced interleukin (IL)-13 responses in mice lacking IL-13 receptor alpha 2. J Exp Med. 2003 Mar 17;197(6):703-9
• All: 21 reference(s)