Exo1^tm1Wed
Targeted Allele Detail

Summary

• Symbol: Exo1^tm1Wed
• Name: exonuclease 1; targeted mutation 1, Winfried Edelmann
• MGI ID: MGI:2653925
• Synonyms: Exo1-, Exo1^mut
• Gene: Exo1 Location: Chr1:175708334-175738962 bp, + strand Genetic Position: Chr1, 81.9 cM
• Alliance: Exo1^tm1Wed page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:82426
• Parent Cell Line: WW6 (ES Cell)
• Strain of Origin: STOCK 129/Sv and C57BL/6J and SJL

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A hygromycin resistance gene cassette was inserted into exon 6 via homologous recombination resulting in disruption of the I-nuclease domain. Disruption of exon 6 in homozygous mutant ES cells was confirmed by northern and Western blot analysis. (J:82426)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Exo1^tm1Wed

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Exo1 Mutation: 46 strains or lines available

References

• Original: J:82426 Wei K, et al., Inactivation of Exonuclease 1 in mice results in DNA mismatch repair defects, increased cancer susceptibility, and male and female sterility. Genes Dev. 2003 Mar 1;17(5):603-14
• All: 14 reference(s)