Rnf2^tm1Mvl
Targeted Allele Detail

Summary

• Symbol: Rnf2^tm1Mvl
• Name: ring finger protein 2; targeted mutation 1, Maarten van Lohuizen
• MGI ID: MGI:2653961
• Synonyms: Rnf2-KO
• Gene: Rnf2 Location: Chr1:151345159-151376562 bp, - strand Genetic Position: Chr1, 64.15 cM
• Alliance: Rnf2^tm1Mvl page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:82399
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129P/Ola

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Two exons encoding a major portion of the ring finger domain was replaced with a neomycin resistance cassette via homologous recombination. The mutant allele was confirmed by RT-PCR analysis of RNA from E9.5 homozygous mutant embryos. (J:82399)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rnf2 Mutation: 36 strains or lines available

References

• Original: J:82399 Voncken JW, et al., Rnf2 (Ring1b) deficiency causes gastrulation arrest and cell cycle inhibition. Proc Natl Acad Sci U S A. 2003 Mar 4;100(5):2468-73
• All: 1 reference(s)