Tg(Neph1-Vegfa)1Seq
Transgene Detail

Summary

• Symbol: Tg(Neph1-Vegfa)1Seq
• Name: transgene insertion 1, Susan E Quaggin
• MGI ID: MGI:2654006
• Transgene: Tg(Neph1-Vegfa)1Seq Location: unknown
• Alliance: Tg(Neph1-Vegfa)1Seq page

Transgene origin

• Strain of Origin: Not Specified

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Neph1-Vegfa)1Seq expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Vegfa (MGI:103178)

• Mutation details: A mouse Neph1 promoter fused to a Vegfa sequence (164 isoform) was used for the transgene. A 4.125 kb fragment of the mouse Neph1 promoter was used to drive transgene expression in podocytes. (J:82440)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

Notes

Two trangenic founders exhibiting 30-fold increased Vegfa expression were created.

References

• Original: J:82440 Eremina V, et al., Glomerular-specific alterations of VEGF-A expression lead to distinct congenital and acquired renal diseases. J Clin Invest. 2003 Mar;111(5):707-16
• All: 1 reference(s)