Tg(SV40-Ahr)1Poe
Transgene Detail

Summary

• Symbol: Tg(SV40-Ahr)1Poe
• Name: transgene insertion 1, Lorenz Poellinger
• MGI ID: MGI:2654022
• Synonyms: CA-AhR
• Transgene: Tg(SV40-Ahr)1Poe Location: unknown
• Alliance: Tg(SV40-Ahr)1Poe page

Transgene origin

• Strain of Origin: (C57BL/6 x CBA)F1

Transgene description

• Transgene Type: Transgenic (Constitutively active, Inserted expressed sequence)
• Mutation: Insertion
• Mutation details: The SV40 promoter and mouse Igh enhancer were used to drive a constitutively active form of the mouse Ahr gene deleted for amino acids 288-421 in the thymus and spleen. The mutant protein is defective in ligand binding. (J:77977)

Expression

In Structures Affected by this Mutation:

8 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Tg(SV40-Ahr)1Poe

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:77977 Andersson P, et al., A constitutively active dioxin/aryl hydrocarbon receptor induces stomach tumors. Proc Natl Acad Sci U S A. 2002 Jul 23;99(15):9990-5
• All: 5 reference(s)