Ddit3^tm1Dron
Targeted Allele Detail

Summary

• Symbol: Ddit3^tm1Dron
• Name: DNA-damage inducible transcript 3; targeted mutation 1, David Ron
• MGI ID: MGI:2654034
• Synonyms: chop-, Chop null
• Gene: Ddit3 Location: Chr10:127126662-127132160 bp, + strand Genetic Position: Chr10, 74.5 cM
• Alliance: Ddit3^tm1Dron page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:52729
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A PGK-neomycin resistance cassette replaced the coding region in parts of exons 3 and 4. Northern blot analyses did not detect transcript in MEFs from homozygous mutant E13.5 embryos. (J:52729)

Expression

In Mice Carrying this Mutation:

3 assay results 1 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Ddit3 Mutation: 20 strains or lines available

References

• Original: J:52729 Zinszner H, et al., CHOP is implicated in programmed cell death in response to impaired function of the endoplasmic reticulum. Genes Dev. 1998 Apr 1;12(7):982-95
• All: 37 reference(s)