Maf^Ofl
Radiation induced Allele Detail

Summary

• Symbol: Maf^Ofl
• Name: MAF bZIP transcription factor; opaque flecks in lens
• MGI ID: MGI:2654153
• Synonyms: J-361
• Gene: Maf Location: Chr8:116429992-116433633 bp, - strand Genetic Position: Chr8, 62.61 cM
• Alliance: Maf^Ofl page

Mutation origin

• Strain of Origin: (C3H/HeEl x 102/El)F1

Mutation description

• Allele Type: Radiation induced
• Mutation: Single point mutation
• Mutation details: The mutation in this mouse was identified as a G to A transition resulting in the amino acid substitution R291Q in the basic region of the DNA binding domain. (J:82475)
• Inheritance: Semidominant

Disease models

Expression

In Structures Affected by this Mutation:

5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Maf Mutation: 27 strains or lines available

References

• Original: J:82475 Lyon MF, et al., A dominant mutation within the DNA-binding domain of the bZIP transcription factor Maf causes murine cataract and results in selective alteration in DNA binding. Hum Mol Genet. 2003 Mar 15;12(6):585-94
• All: 1 reference(s)