Trp53bp1^tm1Jc
Targeted Allele Detail

Summary

• Symbol: Trp53bp1^tm1Jc
• Name: transformation related protein 53 binding protein 1; targeted mutation 1, Junjie Chen
• MGI ID: MGI:2654201
• Synonyms: 53BP1^-, Trp53bp1^delta
• Gene: Trp53bp1 Location: Chr2:121023762-121101888 bp, - strand Genetic Position: Chr2, 60.37 cM
• Alliance: Trp53bp1^tm1Jc page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:82512
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The gene was disrupted by replacement of an exon containing nucleotides 3777 - 4048 with a neomycin resistance cassette via homologous recombination. Absence of gene expression in homozygous mutant animals was confirmed by Western blot analysis using an antibody directed against the N-terminal portion of the protein. (J:82512)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Trp53bp1^tm1Jc

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Trp53bp1 Mutation: 100 strains or lines available

References

• Original: J:82512 Ward IM, et al., p53 Binding protein 53BP1 is required for DNA damage responses and tumor suppression in mice. Mol Cell Biol. 2003 Apr;23(7):2556-63
• All: 60 reference(s)