Gab3^tm1Lrr
Targeted Allele Detail

Summary

• Symbol: Gab3^tm1Lrr
• Name: growth factor receptor bound protein 2-associated protein 3; targeted mutation 1, Larry R Rohrschneider
• MGI ID: MGI:2654214
• Synonyms: Gab3^-
• Gene: Gab3 Location: ChrX:74032151-74128511 bp, - strand Genetic Position: ChrX, 38.12 cM
• Alliance: Gab3^tm1Lrr page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:82505
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutation: Insertion
• Mutation details: Exon 2 was disrupted by a lacZ-neo cassette inserted by homologous recombination. Neither protein nor transcript was detected by RT-PCR and Western blot analysis of homozygous females and hemizygous males, though expression of lacZ was identified in mutant mice. (J:82505)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gab3 Mutation: 8 strains or lines available

References

• Original: J:82505 Seiffert M, et al., Gab3-deficient mice exhibit normal development and hematopoiesis and are immunocompetent. Mol Cell Biol. 2003 Apr;23(7):2415-24
• All: 2 reference(s)