S100a9^tm1Hogg
Targeted Allele Detail

Summary

• Symbol: S100a9^tm1Hogg
• Name: S100 calcium binding protein A9 (calgranulin B); targeted mutation 1, Nancy Hogg
• MGI ID: MGI:2654353
• Synonyms: MRP-14^-
• Gene: S100a9 Location: Chr3:90599939-90603028 bp, - strand Genetic Position: Chr3, 39.91 cM, cytoband F1-F2
• Alliance: S100a9^tm1Hogg page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:82513
• Parent Cell Line: GK129 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutation: Insertion
• Mutation details: Exon 2 was disrupted by the insertion of a lacZ-neo cassette. Normal protein was undetected by immunostaining of splenic sections obtained from homozygous mutant mice. Expression of S100a9 is normal, however, no protein production is observed. (J:82513)

Expression

In Mice Carrying this Mutation:

17 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any S100a9 Mutation: 18 strains or lines available

References

• Original: J:82513 Hobbs JA, et al., Myeloid cell function in MRP-14 (S100A9) null mice. Mol Cell Biol. 2003 Apr;23(7):2564-76
• All: 20 reference(s)