Scarb2^tm1Psa
Targeted Allele Detail

Summary

• Symbol: Scarb2^tm1Psa
• Name: scavenger receptor class B, member 2; targeted mutation 1, Paul Saftig
• MGI ID: MGI:2654430
• Synonyms: LIMP-2^-, LIMP2^-, LIMP-2 KO
• Gene: Scarb2 Location: Chr5:92589170-92653516 bp, - strand Genetic Position: Chr5, 46.82 cM, cytoband E3
• Alliance: Scarb2^tm1Psa page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:82474
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: The gene was disrupted by insertion of a neo cassette into exon 8 via homologous recombination. Absence of gene expression in homozygous mutant animals was confirmed by RT-PCR and Western blot analysis. (J:82474)

Disease models

Expression

In Structures Affected by this Mutation:

18 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Scarb2 Mutation: 64 strains or lines available

References

• Original: J:82474 Gamp AC, et al., LIMP-2/LGP85 deficiency causes ureteric pelvic junction obstruction, deafness and peripheral neuropathy in mice. Hum Mol Genet. 2003 Mar 15;12(6):631-46
• All: 11 reference(s)