Rr308^tm1Fwa
Targeted Allele Detail

Summary

• Symbol: Rr308^tm1Fwa
• Name: regulatory region 308; targeted mutation 1, Frederick W Alt
• MGI ID: MGI:2654435
• Synonyms: Ealpha^N, Tcra^tm1Fwa
• Gene: Rr308 Location: unknown Genetic Position: Chr14, Syntenic
• Alliance: Rr308^tm1Fwa page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:82616
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Modified regulatory region, Null/knockout)
• Mutations: Insertion, Intergenic deletion
• Mutation details: A 1.1 kb fragment containing the Ealpha enhancer was replaced with a loxP site flanked neomycin resistance gene cassette. The silencer upstream and the locus control region (LCR) downstream of Ealpha were not disrupted by the insertion. (J:82616)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rr308 Mutation: 0 strains or lines available

References

• Original: J:82616 Sleckman BP, et al., Function of the TCR alpha enhancer in alphabeta and gammadelta T cells. Immunity. 1997 Oct;7(4):505-15
• All: 1 reference(s)