Rr308^tm2Fwa
Targeted Allele Detail

Summary

• Symbol: Rr308^tm2Fwa
• Name: regulatory region 308; targeted mutation 1, Frederick W Alt
• MGI ID: MGI:2654481
• Synonyms: EalphaCR, Tcra^tm2Fwa
• Gene: Rr308 Location: unknown Genetic Position: Chr14, Syntenic
• Alliance: Rr308^tm2Fwa page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:82395
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Modified regulatory region)
• Mutations: Insertion, Intergenic deletion
• Mutation details: A 1.1 kb fragment containing the Ealpha enhancer was replaced with a 116 bp Ealpha core fragment by homologous and cre-mediated recombination. (J:82395)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rr308 Mutation: 0 strains or lines available

References

• Original: J:82395 Bassing CH, et al., T cell receptor (TCR) alpha/delta locus enhancer identity and position are critical for the assembly of TCR delta and alpha variable region genes. Proc Natl Acad Sci U S A. 2003 Mar 4;100(5):2598-603
• All: 1 reference(s)