Aprt^tm1Vri
Targeted Allele Detail

Summary

• Symbol: Aprt^tm1Vri
• Name: adenine phosphoribosyl transferase; targeted mutation 1, Harry Vrieling
• MGI ID: MGI:2654615
• Synonyms: Aprt^-
• Gene: Aprt Location: Chr8:123301376-123303646 bp, - strand Genetic Position: Chr8, 71.91 cM
• Alliance: Aprt^tm1Vri page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:50874
• Parent Cell Line: IB10/E14IB10 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The gene was disrupted by replacement of the promoter region with a PGK-neo cassette via homologous recombination. Absence of gene expression was confirmed by enzyme assay. Blood from homozygous mutant animals did not contain enzyme activity. (J:50874)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Aprt Mutation: 18 strains or lines available

References

• Original: J:50874 Van Sloun PP, et al., Determination of spontaneous loss of heterozygosity mutations in Aprt heterozygous mice. Nucleic Acids Res. 1998 Nov 1;26(21):4888-94
• All: 2 reference(s)