Robo1^tm1Phr
Targeted Allele Detail

Summary

• Symbol: Robo1^tm1Phr
• Name: roundabout guidance receptor 1; targeted mutation 1, Pamela H Rabbitts
• MGI ID: MGI:2654881
• Synonyms: Dutt1/Robo1 -
• Gene: Robo1 Location: Chr16:72105194-72842983 bp, + strand Genetic Position: Chr16, 41.08 cM
• Alliance: Robo1^tm1Phr page

Lung abnormalities of Robo1^tm1Phr/Robo1^tm1Phr mice

Show the 2 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:73485
• Parent Cell Line: E14TG2a (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin selection cassette replaced a genomic fragment containing exon 2. Western blot analysis demonstrated that reduced levels of a mutant protein was made from this allele that lacked the Ig domain encoded by exon 2. (J:73485)

Disease models

Expression

In Structures Affected by this Mutation:

7 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Robo1^tm1Phr

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Robo1 Mutation: 87 strains or lines available

References

• Original: J:73485 Xian J, et al., Inadequate lung development and bronchial hyperplasia in mice with a targeted deletion in the Dutt1/Robo1 gene. Proc Natl Acad Sci U S A. 2001 Dec 18;98(26):15062-6
• All: 2 reference(s)