Plcb4^tm1Tyo
Targeted Allele Detail

Summary

• Symbol: Plcb4^tm1Tyo
• Name: phospholipase C, beta 4; targeted mutation 1, Tohru Yoshioka
• MGI ID: MGI:2654917
• Gene: Plcb4 Location: Chr2:135500931-135856513 bp, + strand Genetic Position: Chr2, 66.64 cM
• Alliance: Plcb4^tm1Tyo page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:104142
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons encoding amimo acids 539-646 were deleted and replaced with a neomycin resistance cassette via homologous recombination. Absence of gene expression in homozygous mutant mice was confirmed by Western blot analysis of brain proteins. (J:72939, J:104142)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Plcb4 Mutation: 130 strains or lines available

References

• Original: J:104142 Sugiyama T, et al., Localization of phospholipase Cbeta isozymes in the mouse cerebellum. Biochem Biophys Res Commun. 1999 Nov 19;265(2):473-8
• All: 7 reference(s)