Tnfaip6^tm1Cful
Targeted Allele Detail

Summary

• Symbol: Tnfaip6^tm1Cful
• Name: tumor necrosis factor alpha induced protein 6; targeted mutation 1, Csaba Fulop
• MGI ID: MGI:2654926
• Synonyms: Tnfip6^-/-
• Gene: Tnfaip6 Location: Chr2:51928125-51946693 bp, + strand Genetic Position: Chr2, 29.98 cM
• Alliance: Tnfaip6^tm1Cful page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:82539
• Parent Cell Line: TC1/TC-1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 1 was disrupted by a neomycin selection cassette inserted via homologous recombination. Neither transcript nor protein was detected by RT-PCR and Western blot analysis of homozygous mutant embyronic fibroblasts, with and without Tnfa stimulation. (J:82539)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Tnfaip6 Mutation: 23 strains or lines available

References

• Original: J:82539 Fulop C, et al., Impaired cumulus mucification and female sterility in tumor necrosis factor-induced protein-6 deficient mice. Development. 2003 May;130(10):2253-61
• All: 16 reference(s)