Foxp3^tm1Ayr
Targeted Allele Detail

Summary

• Symbol: Foxp3^tm1Ayr
• Name: forkhead box P3; targeted mutation 1, Alexander Y Rudensky
• MGI ID: MGI:2654935
• Synonyms: Foxp3^flox, Foxp3^lox
• Gene: Foxp3 Location: ChrX:7445915-7461482 bp, + strand Genetic Position: ChrX, 3.41 cM
• Alliance: Foxp3^tm1Ayr page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:82560
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: Single loxP sites were left flanking exons 1 through 5 after an FRT site flanked flanked neomycin resistance gene cassette had been excised from intron 5 via in vivo Flp-mediated recombination. (J:82560)

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Foxp3 Mutation: 58 strains or lines available

References

• Original: J:82560 Fontenot JD, et al., Foxp3 programs the development and function of CD4+CD25+ regulatory T cells. Nat Immunol. 2003 Apr;4(4):330-6
• All: 12 reference(s)