Nodal^tm1Hmd
Targeted Allele Detail

Summary

• Symbol: Nodal^tm1Hmd
• Name: nodal growth differentiation factor; targeted mutation 1, Hiroshi Hamada
• MGI ID: MGI:2654943
• Synonyms: Nodal^neo
• Gene: Nodal Location: Chr10:61253751-61261117 bp, + strand Genetic Position: Chr10, 32.21 cM
• Alliance: Nodal^tm1Hmd page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:82703
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Hypomorph, Modified regulatory region)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A floxed PGK-neo cassette was inserted 5 kb upstream of the translation initiation site via homologous recombination, replacing a 0.7 kb region which contains the second left side-specific enhancer (LSE). The resulting allele is hypomorphic. (J:82703)

Expression

In Mice Carrying this Mutation:	6 assay results
In Structures Affected by this Mutation:	6 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Nodal Mutation: 42 strains or lines available

References

• Original: J:82703 Saijoh Y, et al., Left-right patterning of the mouse lateral plate requires nodal produced in the node. Dev Biol. 2003 Apr 1;256(1):160-72
• All: 5 reference(s)