Tbx19^tm1Jdr
Targeted Allele Detail

Summary

• Symbol: Tbx19^tm1Jdr
• Name: T-box 19; targeted mutation 1, Jacques Drouin
• MGI ID: MGI:2655153
• Synonyms: Tpit^-
• Gene: Tbx19 Location: Chr1:164965424-164988342 bp, - strand Genetic Position: Chr1, 72.47 cM, cytoband H2
• Alliance: Tbx19^tm1Jdr page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:82562
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Sequence encompassing a portion of exon 2 and all of exons 3 through 6 was replaced with a vector containing lacZ and neo. The deleted sequence encoded the majority of the T-box. Normal protein was undetected in homozygous mutant mice by immunohistochemical analysis. The lacZ expression pattern was similar to that of the endogenous gene. (J:82562)

Disease models

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tbx19 Mutation: 18 strains or lines available

References

• Original: J:82562 Pulichino AM, et al., Tpit determines alternate fates during pituitary cell differentiation. Genes Dev. 2003 Mar 15;17(6):738-47
• All: 6 reference(s)