Tlx2^tm1Sjk
Targeted Allele Detail

Summary

• Symbol: Tlx2^tm1Sjk
• Name: T cell leukemia, homeobox 2; targeted mutation 1, Stanley J Korsmeyer
• MGI ID: MGI:2655186
• Synonyms: Enx^-, Hox11L1-
• Gene: Tlx2 Location: Chr6:83045306-83047206 bp, - strand Genetic Position: Chr6, 35.94 cM, cytoband C3-D1
• Alliance: Tlx2^tm1Sjk page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:40722
• Parent Cell Line: Other (see notes) (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A 5' portion of exon 1, including the start codon, was replaced with a neomycin selection cassette inserted by homologous recombination. (J:40722)

Disease models

Expression

In Structures Affected by this Mutation:

8 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tlx2 Mutation: 12 strains or lines available

Notes

ES cell line = RW-4 (129X1/SvJ) or GS1 (129/Sv); see J:40722.

References

• Original: J:40722 Shirasawa S, et al., Enx (Hox11L1)-deficient mice develop myenteric neuronal hyperplasia and megacolon. Nat Med. 1997 Jun;3(6):646-50
• All: 2 reference(s)