Slc1a1^tm1Wst
Targeted Allele Detail

Summary

• Symbol: Slc1a1^tm1Wst
• Name: solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1; targeted mutation 1, Wilheim Stoffel
• MGI ID: MGI:2655190
• Synonyms: eaac-1 -, EAAC1-, EAAT3-
• Gene: Slc1a1 Location: Chr19:28812535-28891360 bp, + strand Genetic Position: Chr19, 23.5 cM
• Alliance: Slc1a1^tm1Wst page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:41613
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: A neomycin selection cassette was inserted into exon 1 by homologous recombination. Northern blot analysis demonstrated that no detectable mRNA was expressed from this allele. (J:41613)

Disease models

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Slc1a1 Mutation: 34 strains or lines available

References

• Original: J:41613 Peghini P, et al., Glutamate transporter EAAC-1-deficient mice develop dicarboxylic aminoaciduria and behavioral abnormalities but no neurodegeneration. EMBO J. 1997 Jul 1;16(13):3822-32
• All: 39 reference(s)