Six1^tm1Mair
Targeted Allele Detail

Summary

• Symbol: Six1^tm1Mair
• Name: sine oculis-related homeobox 1; targeted mutation 1, Pascal Maire
• MGI ID: MGI:2655195
• Synonyms: Six1-, Six1^lacZ
• Gene: Six1 Location: Chr12:73088601-73093486 bp, - strand Genetic Position: Chr12, 30.34 cM
• Alliance: Six1^tm1Mair page

Spectrum of abnormalities of great artery patterning in mice with null mutation of one or both copies of Six1^tm1Mair and Eya1^tm1Rilm

Show the 4 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:82459
• Parent Cell Line: MPI-II (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The N-terminal portion of the gene was deleted by replacement of exon 1 with a lacZ-PGK-neo cassette via homologous recombination. Absence of gene expression in homozygous mutant animals was confirmed by immunohistochemical analysis. (J:82459)

Expression

In Mice Carrying this Mutation:	358 assay results 3 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	42 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Six1 Mutation: 19 strains or lines available

Notes

These ES cells were additionally targeted in J:98519 to create Six1Six4 double knockouts.

References

• Original: J:82459 Laclef C, et al., Altered myogenesis in Six1-deficient mice. Development. 2003 May;130(10):2239-52
• All: 34 reference(s)