Ptch1^tm2Mps
Targeted Allele Detail

Summary

• Symbol: Ptch1^tm2Mps
• Name: patched 1; targeted mutation 2, Matthew P Scott
• MGI ID: MGI:2655210
• Synonyms: ptch^D11
• Gene: Ptch1 Location: Chr13:63656142-63721274 bp, - strand Genetic Position: Chr13, 32.8 cM
• Alliance: Ptch1^tm2Mps page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:82653
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Hypomorph, Reporter)
• Mutation: Insertion
• Mutation details: This hypomorphic allele containing lacZ was derived through an aberrant recombination event while generating Ptch^tm1Mps. The expression pattern of lacZ matches that of the endogenous gene. (J:82653)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ptch1 Mutation: 115 strains or lines available

References

• Original: J:82653 Oro AE, et al., Hair cycle regulation of Hedgehog signal reception. Dev Biol. 2003 Mar 15;255(2):238-48
• All: 7 reference(s)