Tbx3^tm1Pa
Targeted Allele Detail

Summary

• Symbol: Tbx3^tm1Pa
• Name: T-box 3; targeted mutation 1, Virginia Papaioannou
• MGI ID: MGI:2655214
• Gene: Tbx3 Location: Chr5:119808734-119822789 bp, + strand Genetic Position: Chr5, 60.34 cM
• Alliance: Tbx3^tm1Pa page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:82458
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A 3.2 kb genomic fragment encompassing 3 exons was replaced with a floxed selection cassette that was subsequently removed in vitro via cre mediated excision. A single loxP site was left in place of exons 2, 2a, and 3, which encoded 158 residues of the T domain. (J:82458)

Disease models

Expression

In Mice Carrying this Mutation:	26 assay results
In Structures Affected by this Mutation:	18 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Tbx3 Mutation: 49 strains or lines available

References

• Original: J:82458 Davenport TG, et al., Mammary gland, limb and yolk sac defects in mice lacking Tbx3, the gene mutated in human ulnar mammary syndrome. Development. 2003 May;130(10):2263-73
• All: 8 reference(s)