Rr27^tm1.1Kpfe
Targeted Allele Detail

Summary

• Symbol: Rr27^tm1.1Kpfe
• Name: regulatory region 27; targeted mutation 1.1, Karl Pfeifer
• MGI ID: MGI:2655219
• Synonyms: DMR^DeltaG, H19^tm1.1Kpfe
• Gene: Rr27 Location: Chr7:142133885-142136283 bp Genetic Position: Chr7, Syntenic
• Alliance: Rr27^tm1.1Kpfe page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:82798
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Modified regulatory region, Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The floxed 0.1 kb region containing the differentially methylated region (DMR) was excised from Rr27^tm1Kpfe via cre-mediated recombination in the germ line. (J:82798)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rr27 Mutation: 7 strains or lines available

References

• Original: J:82798 Srivastava M, et al., H19 and Igf2 monoallelic expression is regulated in two distinct ways by a shared cis acting regulatory region upstream of H19. Genes Dev. 2000 May 15;14(10):1186-95
• All: 3 reference(s)