Grin1^tm1Slab
Targeted Allele Detail

Summary

• Symbol: Grin1^tm1Slab
• Name: glutamate receptor, ionotropic, NMDA1 (zeta 1); targeted mutation 1, Ralf Schoepfer
• MGI ID: MGI:2655224
• Synonyms: NR1^Rneo
• Gene: Grin1 Location: Chr2:25181193-25209199 bp, - strand Genetic Position: Chr2, 17.14 cM
• Alliance: Grin1^tm1Slab page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:82670
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Nucleotide substitutions
• Mutation details: An asparagine to arginine subsitution at amino acid 598 (N598R) was introduced into exon 15 via homologous recombination. A floxed neo cassette was inserted into intron 18 for positive selection. The neo insertion was found to disrupt gene expression. (J:82670)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Grin1 Mutation: 66 strains or lines available

References

• Original: J:82670 Rudhard Y, et al., Absence of Whisker-related pattern formation in mice with NMDA receptors lacking coincidence detection properties and calcium signaling. J Neurosci. 2003 Mar 15;23(6):2323-32
• All: 2 reference(s)