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Grin1tm1.1Slab
Targeted Allele Detail
Summary
Symbol: Grin1tm1.1Slab
Name: glutamate receptor, ionotropic, NMDA1 (zeta 1); targeted mutation 1.1 Ralf Schoepfer
MGI ID: MGI:2655232
Synonyms: NR1R
Gene: Grin1  Location: Chr2:25181193-25209199 bp, - strand  Genetic Position: Chr2, 17.14 cM
Alliance: Grin1tm1.1Slab page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:82670
Parent Cell Line:  E14 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted
Mutation:    Nucleotide substitutions
 
Mutation detailsThis allele is derived from Grin1tm1Slab by mating mutant animals to cre deleter strain TgN(CMV-cre)1Cgn, resulting in removal of the floxed neo cassette in intron 18 and allowing the asparagine to arginine subsitution at amino acid 598 (N598R) to be expressed. Western blot analysis showed that expression of the mutant allele is comparable to that of wild-type. (J:82670)
Inheritance:    Dominant
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 2 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Grin1 Mutation:  67 strains or lines available
References
Original:  J:82670 Rudhard Y, et al., Absence of Whisker-related pattern formation in mice with NMDA receptors lacking coincidence detection properties and calcium signaling. J Neurosci. 2003 Mar 15;23(6):2323-32
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
12/10/2024
MGI 6.24
The Jackson Laboratory