Grin1^tm1.1Slab
Targeted Allele Detail

Summary

• Symbol: Grin1^tm1.1Slab
• Name: glutamate receptor, ionotropic, NMDA1 (zeta 1); targeted mutation 1.1 Ralf Schoepfer
• MGI ID: MGI:2655232
• Synonyms: NR1^R
• Gene: Grin1 Location: Chr2:25181193-25209199 bp, - strand Genetic Position: Chr2, 17.14 cM
• Alliance: Grin1^tm1.1Slab page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:82670
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted
• Mutation: Nucleotide substitutions
• Mutation details: This allele is derived from Grin1^tm1Slab by mating mutant animals to cre deleter strain TgN(CMV-cre)1Cgn, resulting in removal of the floxed neo cassette in intron 18 and allowing the asparagine to arginine subsitution at amino acid 598 (N598R) to be expressed. Western blot analysis showed that expression of the mutant allele is comparable to that of wild-type. (J:82670)
• Inheritance: Dominant

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Grin1 Mutation: 66 strains or lines available

References

• Original: J:82670 Rudhard Y, et al., Absence of Whisker-related pattern formation in mice with NMDA receptors lacking coincidence detection properties and calcium signaling. J Neurosci. 2003 Mar 15;23(6):2323-32
• All: 2 reference(s)