Hoxb13^tm1Mrc
Targeted Allele Detail

Summary

• Symbol: Hoxb13^tm1Mrc
• Name: homeobox B13; targeted mutation 1, Mario R Capecchi
• MGI ID: MGI:2655241
• Synonyms: Hoxb13^lacZ, Hoxb13^lacZlxp
• Gene: Hoxb13 Location: Chr11:96085142-96087436 bp, + strand Genetic Position: Chr11, 59.63 cM
• Alliance: Hoxb13^tm1Mrc page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:82540
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: LacZ was left in place of codon 33 in exon 2 after the floxed neo cassette was removed from Hoxb13^tm3Mrc via cre mediated recombination. The expression pattern of lacZ was identical to that of the endogenous gene. (J:82540, J:82849)

Expression

In Structures Affected by this Mutation:

10 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Hoxb13 Mutation: 9 strains or lines available

References

• Original: J:82540 Economides KD, et al., Hoxb13 is required for normal differentiation and secretory function of the ventral prostate. Development. 2003 May;130(10):2061-9
• All: 2 reference(s)