Stmn1^tm1Wed
Targeted Allele Detail

Summary

• Symbol: Stmn1^tm1Wed
• Name: stathmin 1; targeted mutation 1, Winfried Edelmann
• MGI ID: MGI:2655259
• Synonyms: metablastin -, stathmin -
• Gene: Stmn1 Location: Chr4:134195631-134201154 bp, + strand Genetic Position: Chr4, 66.76 cM
• Alliance: Stmn1^tm1Wed page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:33563
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin selection cassette replaced a genomic fragment containing exons 2 and 3. Northern blot analysis demonstrated that no detectable mRNA was expressed from this allele, and western blot analysis on brain extracts derived from homozygous mice showed that no detectable encoded protein was present. (J:33563)

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Stmn1 Mutation: 31 strains or lines available

References

• Original: J:33563 Schubart UK, et al., Normal development of mice lacking metablastin (P19), a phosphoprotein implicated in cell cycle regulation. J Biol Chem. 1996 Jun 14;271(24):14062-6
• All: 17 reference(s)