Anxa5^tm1Epo
Targeted Allele Detail

Summary

• Symbol: Anxa5^tm1Epo
• Name: annexin A5; targeted mutation 1, Ernst Poeschl
• MGI ID: MGI:2655676
• Synonyms: Anxa5^lacZ
• Gene: Anxa5 Location: Chr3:36503072-36530036 bp, - strand Genetic Position: Chr3, 17.46 cM
• Alliance: Anxa5^tm1Epo page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:82739
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Homologous recombination of targeting construct containing lacZ and neo replaced sequence encompassing a portion of exon 3, all of exon 4, and the murine endogenous retrovirus (MuERV) within intron 4 of the 129 genetic background. The lacZ sequence was fused in frame with the second start codon of exon 3, which is common to all known isoforms. While no full length transcripts were identified in homozygous mutant mice, aberrantly spliced truncated transcripts were detected, though no protein was detected by Western blot or immunohistochemical analysis. (J:82739)

Expression

In Mice Carrying this Mutation:

22 assay results 1 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Anxa5 Mutation: 24 strains or lines available

References

• Original: J:82739 Brachvogel B, et al., Annexin A5 is not essential for skeletal development. Mol Cell Biol. 2003 Apr;23(8):2907-13
• All: 10 reference(s)