Camk2a^tm1Vyb
Targeted Allele Detail

Summary

• Symbol: Camk2a^tm1Vyb
• Name: calcium/calmodulin-dependent protein kinase II alpha; targeted mutation 1, Vadim Y Bolshakov
• MGI ID: MGI:2655688
• Synonyms: falpha-CaMKII KO
• Gene: Camk2a Location: Chr18:61058704-61121224 bp, + strand Genetic Position: Chr18, 34.41 cM
• Alliance: Camk2a^tm1Vyb page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:82744
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was introduced into intron 1 and an frt/loxP-flanked neo cassette was introduced to intron 2 via homologous recombination. The neo cassette was removed by transient expression of flp recombinase in correctly targeted ES cells. Resulting mutant mice carry a floxed exon 2 allele. (J:82744)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Camk2a Mutation: 135 strains or lines available

References

• Original: J:82744 Hinds HL, et al., Essential function of alpha-calcium/calmodulin-dependent protein kinase II in neurotransmitter release at a glutamatergic central synapse. Proc Natl Acad Sci U S A. 2003 Apr 1;100(7):4275-80
• All: 3 reference(s)