Bdnf^{tm1(Ntf3)Pern}
Targeted Allele Detail

Summary

• Symbol: Bdnf^{tm1(Ntf3)Pern}
• Name: brain derived neurotrophic factor; targeted mutation 1, Patrik Ernfors
• MGI ID: MGI:2655761
• Synonyms: BDNF^NT3
• Gene: Bdnf Location: Chr2:109505045-109557352 bp, + strand Genetic Position: Chr2, 56.63 cM
• Alliance: Bdnf^{tm1(Ntf3)Pern} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:82462
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted
• Mutation: Insertion
• Mutation details: The gene was disrupted by an in-frame fusion of the Nfg3 protein coding sequence and a floxed neo cassette with exon 5. Gene expression was absent in homozygous mutant animals as determined by ELISA assay. Instead, expression of Ntf3 corresponded to the expression pattern of Bdnf in mutant animals. (J:82462)

Expression

In Structures Affected by this Mutation:

7 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Bdnf Mutation: 42 strains or lines available

References

• Original: J:82462 Agerman K, et al., BDNF gene replacement reveals multiple mechanisms for establishing neurotrophin specificity during sensory nervous system development. Development. 2003 Apr;130(8):1479-91
• All: 2 reference(s)