St3gal5^tm1Rlp
Targeted Allele Detail

Summary

• Symbol: St3gal5^tm1Rlp
• Name: ST3 beta-galactoside alpha-2,3-sialyltransferase 5; targeted mutation 1, Richard L Proia
• MGI ID: MGI:2655771
• Synonyms: GM3S^-, Siat9^-
• Gene: St3gal5 Location: Chr6:72074576-72131555 bp, + strand Genetic Position: Chr6, 32.24 cM, cytoband C3
• Alliance: St3gal5^tm1Rlp page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:82723
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 4 was replaced with a neomycin selection cassette inserted by homologous recombination. Transcript was undetected by Northern blot analysis of brain RNA obtained from homozygous mutant mice. (J:82723)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any St3gal5 Mutation: 25 strains or lines available

References

• Original: J:82723 Yamashita T, et al., Enhanced insulin sensitivity in mice lacking ganglioside GM3. Proc Natl Acad Sci U S A. 2003 Mar 18;100(6):3445-9
• All: 25 reference(s)