Fbxo15^tm1Yam
Targeted Allele Detail

Summary

• Symbol: Fbxo15^tm1Yam
• Name: F-box protein 15; targeted mutation 1, Shinya Yamanaka
• MGI ID: MGI:2655776
• Gene: Fbxo15 Location: Chr18:84952907-84999598 bp, + strand Genetic Position: Chr18, 57.53 cM
• Alliance: Fbxo15^tm1Yam page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:82741
• Parent Cell Line: RF8 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A beta-geo cassette replaced exons 3 through 7. The deleted region encoded the F box. Neither transript nor protein was detected by Northern and Western blot analyses of homozygous mutant mice. The beta-galactosidase expression pattern was similar to that of the endogenous gene. (J:82741)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Fbxo15 Mutation: 111 strains or lines available

References

• Original: J:82741 Tokuzawa Y, et al., Fbx15 is a novel target of Oct3/4 but is dispensable for embryonic stem cell self-renewal and mouse development. Mol Cell Biol. 2003 Apr;23(8):2699-708
• All: 2 reference(s)