Rnaseh1^tm1Crh
Targeted Allele Detail

Summary

• Symbol: Rnaseh1^tm1Crh
• Name: ribonuclease H1; targeted mutation 1, Robert J Crouch
• MGI ID: MGI:2655784
• Synonyms: Rnaseh1
• Gene: Rnaseh1 Location: Chr12:28699601-28709588 bp, + strand Genetic Position: Chr12, 10.99 cM, cytoband A3
• Alliance: Rnaseh1^tm1Crh page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:82764
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The gene was disrupted by replacement of exons 2-4 with a PGK-neo cassette via homologous recombination. (J:82764)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rnaseh1 Mutation: 34 strains or lines available

References

• Original: J:82764 Cerritelli SM, et al., Failure to produce mitochondrial DNA results in embryonic lethality in Rnaseh1 null mice. Mol Cell. 2003 Mar;11(3):807-15
• All: 1 reference(s)