Pnpla6^tm1Blw
Targeted Allele Detail

Summary

• Symbol: Pnpla6^tm1Blw
• Name: patatin-like phospholipase domain containing 6; targeted mutation 1, Carrolee Barlow
• MGI ID: MGI:2655812
• Synonyms: Nte^-
• Gene: Pnpla6 Location: Chr8:3565384-3594267 bp, + strand Genetic Position: Chr8, 1.92 cM
• Alliance: Pnpla6^tm1Blw page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:82791
• Parent Cell Line: TC1/TC-1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The gene was disrupted by an in-frame fusion of lacZ to exon 4 and replacement of exons 5-10 with a neomycin resistance gene. (J:82791)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Pnpla6 Mutation: 63 strains or lines available

References

• Original: J:82791 Winrow CJ, et al., Loss of neuropathy target esterase in mice links organophosphate exposure to hyperactivity. Nat Genet. 2003 Apr;33(4):477-85
• All: 2 reference(s)