Nkx2-9^tm1Hha
Targeted Allele Detail

Summary

• Symbol: Nkx2-9^tm1Hha
• Name: NK2 homeobox 9; targeted mutation 1, Hans-Henning Arnold
• MGI ID: MGI:2655862
• Gene: Nkx2-9 Location: Chr12:56658174-56660069 bp, - strand Genetic Position: Chr12, 24.47 cM
• Alliance: Nkx2-9^tm1Hha page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:81765
• Parent Cell Line: TBV2 (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: All of exon 1 and a portion of exon 2 were replaced with a lacZ-neo cassette inserted by homologous recombination. The deleted region included the homeodomain. No transcript was detected in homozygous mutant brain tissue by RT-PCR analysis or in situ hybridization. (J:81765)

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Nkx2-9 Mutation: 8 strains or lines available

References

• Original: J:81765 Pabst O, et al., Targeted disruption of the homeobox gene Nkx2.9 reveals a role in development of the spinal accessory nerve. Development. 2003 Mar;130(6):1193-202
• All: 5 reference(s)