Pdgfratm6Sor
Targeted Allele Detail
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Symbol: |
Pdgfratm6Sor |
Name: |
platelet derived growth factor receptor, alpha polypeptide; targeted mutation 6, Philippe Soriano |
MGI ID: |
MGI:2656147 |
Synonyms: |
alphaSrc |
Gene: |
Pdgfra Location: Chr5:75312953-75358876 bp, + strand Genetic Position: Chr5, 39.55 cM
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Alliance: |
Pdgfratm6Sor page
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Germline Transmission: |
Earliest citation of germline transmission:
J:73817
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Parent Cell Line: |
AK7 (ES Cell)
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Strain of Origin: |
129S4/SvJaeSor
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Allele Type: |
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Targeted (Hypomorph, Inserted expressed sequence) |
Mutation: |
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Insertion
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Mutation details: A cDNA encoding a mutated receptor consisting of point mutations encoding the tyrosine 572/574 sites was targeted into the Pdgfra locus. Western blot analysis indicated that expression of the targeted Pdgfra locus was disrupted and the mutant receptor was expressed.
(J:73817)
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Pdgfra Mutation: |
86 strains or lines available
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Original: |
J:73817 Klinghoffer RA, et al., An allelic series at the PDGFalphaR locus indicates unequal contributions of distinct signaling pathways during development. Dev Cell. 2002 Jan;2(1):103-13 |
All: |
2 reference(s) |
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