Iapp^tm1Sgm
Targeted Allele Detail

Summary

• Symbol: Iapp^tm1Sgm
• Name: islet amyloid polypeptide; targeted mutation 1, Samuel Gebre-Medhin
• MGI ID: MGI:2656235
• Synonyms: Amylin -, IAPP^-
• Gene: Iapp Location: Chr6:142244151-142249546 bp, + strand Genetic Position: Chr6, 73.81 cM
• Alliance: Iapp^tm1Sgm page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:50042
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The gene was disrupted by replacement of exon 3 with a neomycin resistance cassette via homologous recombination. Absence of gene expression was confirmed by immunohistochemical analysis of islet cells from homozygous mutant animals. (J:50042)

Expression

In Structures Affected by this Mutation:

5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Iapp Mutation: 14 strains or lines available

References

• Original: J:50042 Gebre-Medhin S, et al., Increased insulin secretion and glucose tolerance in mice lacking islet amyloid polypeptide (amylin). Biochem Biophys Res Commun. 1998 Sep 18;250(2):271-7
• All: 18 reference(s)