St8sia1^tm1Kfk
Targeted Allele Detail

Summary

• Symbol: St8sia1^tm1Kfk
• Name: ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1; targeted mutation 1, Koichi Furukawa
• MGI ID: MGI:2656251
• Synonyms: GD3s-KO, Sia-T^-
• Gene: St8sia1 Location: Chr6:142767271-142910178 bp, - strand Genetic Position: Chr6, 74.78 cM
• Alliance: St8sia1^tm1Kfk page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:73818
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The gene was disrupted by insertion of a neomycin resistance cassette into exon 1 via homologous recombination. Enzyme activity was absent from brain tissue extracts derived from homozygous mutant animals. (J:73818)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any St8sia1 Mutation: 30 strains or lines available

References

• Original: J:73818 Okada M, et al., b-series Ganglioside deficiency exhibits no definite changes in the neurogenesis and the sensitivity to Fas-mediated apoptosis but impairs regeneration of the lesioned hypoglossal nerve. J Biol Chem. 2002 Jan 18;277(3):1633-6
• All: 19 reference(s)