Sell^tm1Alb
Targeted Allele Detail

Summary

• Symbol: Sell^tm1Alb
• Name: selectin, lymphocyte; targeted mutation 1, Arthur L Beaudet
• MGI ID: MGI:2656258
• Synonyms: Sell^tm1Bay
• Gene: Sell Location: Chr1:163889556-163908354 bp, + strand Genetic Position: Chr1, 71.37 cM
• Alliance: Sell^tm1Alb page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:70682
• Parent Cell Line: AB2.1 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd-Hprt1^b-m2

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: The gene was disrupted by insertion of a puromycin resistance cassette in opposite orientation into the coding sequence via homologous recombination. The construct was injected into ES cells already carrying mutations in Sele and Selp. Clones where the targeting vector inserted in trans to the Sele and Selp mutations were used to produce single Sell mutant mice. Absence of gene expression was confirmed by flow cytometric analysis of leukocytes from homozygous mutant animals. (J:70682)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Sell Mutation: 42 strains or lines available

References

• Original: J:70682 Collins RG, et al., Dermal and pulmonary inflammatory disease in E-selectin and P-selectin double-null mice is reduced in triple-selectin-null mice. Blood. 2001 Aug 1;98(3):727-35
• All: 1 reference(s)