Gja8^tm1(Gja3)Tww
Targeted Allele Detail

Summary

• Symbol: Gja8^tm1(Gja3)Tww
• Name: gap junction protein, alpha 8; targeted mutation 1, Thomas W White
• MGI ID: MGI:2656266
• Synonyms: 46, alpha8(KIalpha3), Cx50KI46
• Gene: Gja8 Location: Chr3:96820882-96833336 bp, - strand
• Alliance: Gja8^tm1(Gja3)Tww page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:73875
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted
• Mutations: Insertion, Intragenic deletion
• Mutation details: The entire endogenous coding region was replaced with sequence enocoding Gja3. Transcription and translation of the inserted sequence, as well as the ablation of endogenous expression, were verified by Northern and Western blot analyses. Immunocytochemical analysis of homozygous mutant mice verified proper Gja3 protein in fiber gap junctions. (J:73875)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gja8 Mutation: 33 strains or lines available

References

• Original: J:73875 White TW, Unique and redundant connexin contributions to lens development. Science. 2002 Jan 11;295(5553):319-20
• All: 9 reference(s)