Ntrk3^tm1Kln
Targeted Allele Detail

Summary

• Symbol: Ntrk3^tm1Kln
• Name: neurotrophic tyrosine kinase, receptor, type 3; targeted mutation 1, Rudiger Klein
• MGI ID: MGI:2656335
• Synonyms: trkC^shc
• Gene: Ntrk3 Location: Chr7:77825711-78228865 bp, - strand Genetic Position: Chr7, 44.01 cM
• Alliance: Ntrk3^tm1Kln page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:75365
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Not Specified)
• Mutation: Nucleotide substitutions
• Mutation details: A tyrosine to phenylalanine substitution was introduced at residue 516 (Y516F) of the Shc adaptor binding site and a floxed neo cassette was inserted into the upstream intron via homologous recombination. The neo cassette was removed by mating mutant animals to cre deleter line TgN(CMV-cre)1Cgn. (J:75365)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ntrk3 Mutation: 67 strains or lines available

References

• Original: J:75365 Postigo A, et al., Distinct requirements for TrkB and TrkC signaling in target innervation by sensory neurons. Genes Dev. 2002 Mar 1;16(5):633-45
• All: 1 reference(s)